The goal of this concept is to continue supporting an integrated BRAIN® Initiative Cell Atlas Network (BICAN) Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will (i) enable the exploration of large-scale brain cell atlas data and knowledge, (ii) inspire research in brain function and disorders, and (iii) ensure research rigor and data reproducibility by making the data Findable, Accessible, Interoperable, and Reusable (FAIR). This will provide the foundation for a knowledge base with consensus brain cell taxonomies, ontologies, and community data standards.

This is a reissue of the informatics infrastructure program announcement for The Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative data ecosystem. This program has established domain-specific archives that serve as primary repositories for scientific data generated across the BRAIN research portfolio, providing long-term maintenance, standardized curation, compliance with NIH data management and sharing policy, and broad community access. This concept calls for continued support for the data archive component of that infrastructure.

The goal of this concept is to reissue and extend the NIMH Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers program. The ALACRITY Centers program is intended to support high-impact, practice-based research with near-term potential to significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States.

The goal of this concept is to generate comprehensive evidence to determine whether immunotherapeutic strategies, including broadly neutralizing antibodies (bNAbs) and antibody-derived constructs, can safely and effectively target HIV persistence within the central nervous system (CNS) compartment while mitigating neuroimmune dysfunction and improving mental health outcomes.